anti-HER2 monoclonal antibody BAT1006

{
  "id": "MLC-T-ONC-010752",
  "term": "anti-HER2 monoclonal antibody BAT1006",
  "field": "Oncology and biomedicine",
  "definition": "A glycosylation engineered recombinant humanized monoclonal antibody targeting the extracellular dimerization domain (subdomain II) of the tumor-associated antigen (TAA) and tyrosine kinase receptor epidermal growth factor receptor 2 (HER2; ErbB2; HER-2), with potential antineoplastic activity. Upon administration, anti-HER2 monoclonal antibody BAT1006 targets and binds to HER2 on tumor cells, thereby blocking HER2-mediated signaling. This may inhibit the proliferation of HER2-expressing tumor cells. In addition, BAT1006 induces antibody-dependent cell-mediated cytotoxicity (ADCC). HER2, overexpressed on a variety of tumor cell types, plays an important role in tumor cell proliferation, differentiation and survival.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-her2-monoclonal-antibody-bat1006/"
}