HER2-targeted hypoxia-stimulated CAR T cells

{
  "id": "MLC-T-ONC-014105",
  "term": "HER2-targeted hypoxia-stimulated CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of T lymphocytes that have been genetically modified to express a hypoxia-stimulated chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) human epidermal growth factor 2 (HER2; ErbB2; HER-2), with potential immunostimulating and antineoplastic activities. Upon administration, HER2-targeted hypoxia-stimulated CAR T cells target and bind to HER2-expressing tumor cells, thereby inducing selective toxicity in HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation. Hypoxia-stimulated CAR may improve the expansion and survival of the CAR T cells in the hypoxic tumor microenvironment (TME).",
  "synonyms": [
    "HypoSti.CAR-HER2 T cells",
    "anti-HER2 hypoxia-stimulated CAR T cells",
    "HER2 targeted HypoSti.CAR-T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/her2-targeted-hypoxia-stimulated-car-t-cells/"
}