anti-HER2/anti-CD3 bispecific antibody M802

{
  "id": "MLC-T-ONC-010756",
  "term": "anti-HER2/anti-CD3 bispecific antibody M802",
  "field": "Oncology and biomedicine",
  "definition": "A humanized bispecific antibody composed of a monovalent unit directed against the tumor-associated antigen (TAA) human epidermal growth factor 2 (HER2; ErbB2; HER-2) and a single chain unit directed against CD3 found on T lymphocytes, with potential immunostimulatory and antineoplastic activities. Upon administration, anti-HER2/anti-CD3 bispecific antibody M802 binds to both CD3 on cytotoxic T lymphocytes (CTLs) and HER2 on HER2-expressing tumor cells. This activates and redirects CTLs to HER2-expressing tumor cells, which results in the CTL-mediated cell death of HER2-expressing tumor cells. HER2 is overexpressed in a variety of cancer cell types and is associated with increased tumor cell proliferation.",
  "synonyms": [
    "HER2 x CD3 bispecific antibody M802"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-her2-anti-cd3-bispecific-antibody-m802/"
}