tri-virus/GD2-specific allogeneic cytotoxic T-lymphocytes

{
  "id": "MLC-T-ONC-017336",
  "term": "tri-virus/GD2-specific allogeneic cytotoxic T-lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Allogeneic tri-viral specific, Epstein-Barr virus (EBV), cytomegalovirus (CMV) and adenovirus (Ad), cytotoxic T-lymphocytes (tV-CTLs) expressing a chimeric antigen receptor (CAR) specific for disialoganglioside GD2 with potential antineoplastic activity. Tri-virus/GD2-specific allogeneic CTLs are produced by transducing tV-CTLs with a GD2-specific CAR retroviral vector. Upon administration, after an allogeneic hematopoietic stem cell transplant, these CTLs may be selective towards EBV, CMV, and Ad-infected cells and GD2-expressing tumor cells. The human glycosphingolipid GD2 is a tumor associated antigen overexpressed on the surface of all tumors of neuroectodermal origin.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tri-virus-gd2-specific-allogeneic-cytotoxic-t-lymphocytes/"
}