GD2-CAR-expressing autologous T-lymphocytes

{
  "id": "MLC-T-ONC-013915",
  "term": "GD2-CAR-expressing autologous T-lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "Genetically modified, autologous T-lymphocytes transduced with a retroviral vector encoding a 14g2a.zeta chimeric antigen receptor (CAR) directed against the disialoganglioside GD2, with potential immunomodulating and antineoplastic activities. Upon intravenous administration, the activated T-lymphocytes target the GD2 antigen on tumor cells and selectively kill those cells. The tumor-associated antigen GD2 is overexpressed on the surface of almost all tumors of neuroectodermal origin.",
  "synonyms": [
    "tvs-CTL vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gd2-car-expressing-autologous-t-lymphocytes/"
}