GD2 lactone/GD3 lactone-KLH conjugate bivalent vaccine

{
  "id": "MLC-T-ONC-013914",
  "term": "GD2 lactone/GD3 lactone-KLH conjugate bivalent vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine, containing epitopes of the gangliosides GD2 and GD3 conjugated with the immunostimulant keyhole limpet hemocyanin (KLH), with potential antineoplastic activity. Vaccination with GD2 lactone/GD3 lactone-KLH conjugate bivalent vaccine may elicit antibodies against tumor cells expressing either epitope, resulting in complement-mediated cytotoxicity (CMC) and antibody-dependent cell-mediated cytotoxicity (ADCC). Located primarily in the nervous system, gangliosides, such as GD2 and GD3, are cell membrane components involved in cellular recognition and cell-cell communication.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gd2-lactone-gd3-lactone-klh-conjugate-bivalent-vaccine/"
}