anti-GD3 antibody-drug conjugate PF-06688992

{
  "id": "MLC-T-ONC-010693",
  "term": "anti-GD3 antibody-drug conjugate PF-06688992",
  "field": "Oncology and biomedicine",
  "definition": "An antibody-drug conjugate (ADC) composed of a monoclonal antibody against the ganglioside GD3, a surface antigen expressed on many malignant melanoma cells, and linked to an as of yet not fully elucidated chemotherapeutic agent, with potential antineoplastic activity. Upon administration of the ADC PF-06688992, the antibody moiety targets and binds to GD3 expressed on melanoma cells. Upon internalization, the chemotherapeutic agent specifically kills the GD3-positive cells. GD3 represents a major surface marker on most human melanoma cells and is not expressed on most other types of normal, healthy cells.",
  "synonyms": [
    "GD3 ADC PF-06688992",
    "anti-GD3 ADC PF-06688992"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-gd3-antibody-drug-conjugate-pf-06688992/"
}