GM2/GD2/GD3 lactone-KLH conjugate trivalent vaccine

{
  "id": "MLC-T-ONC-013991",
  "term": "GM2/GD2/GD3 lactone-KLH conjugate trivalent vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A trivalent cancer vaccine containing the ganglioside lactones GM2, GD2 and GD3 conjugated with the immunostimulant keyhole limpet hemocyanin (KLH), with potential antineoplastic activity. Vaccination with GM2 lactone/GD2 lactone/GD3 lactone-KLH conjugate trivalent vaccine may elicit antibodies against tumor cells expressing any of these epitopes, resulting in an antibody-dependent cell-mediated cytotoxicity (ADCC) against tumor cells expressing these gangliosides. GM2, GD2 and GD3 are tumor associated antigens (TAAs) that are overexpressed in a variety of tumor cell membranes.",
  "synonyms": [
    "GM2 lactone/GD2 lactone/GM3 lactone-KLH conjugate trivalent vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gm2-gd2-gd3-lactone-klh-conjugate-trivalent-vaccine/"
}