PEP-3-KLH conjugate vaccine

{
  "id": "MLC-T-ONC-015950",
  "term": "PEP-3-KLH conjugate vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine consisting of PEP-3, a synthetic peptide encompassing a tumor-specific mutated segment of the epidermal growth factor receptor type vIII (EGFRvIII), conjugated to the naturally-occuring immunoadjuvant keyhole limpet hemocyanin (KLH) with potential immunostimulating and antineoplastic activities. Upon administration, PEP-3-KLH conjugate vaccine may induce a cytotoxic immune response against tumor cells that overexpress EGFRvIII; this antitumoral immune response may involve antibody-dependent cellular cytotoxicity (ADCC).",
  "abbreviation": "PEP-3-KLH",
  "synonyms": [
    "PEPvIII-KLH conjugate vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/pep-3-klh-conjugate-vaccine/"
}