allogeneic third-party suicide gene-transduced anti-HLA-DPB1*0401 CD4+ T cells CTL 19

{
  "id": "MLC-T-ONC-009950",
  "term": "allogeneic third-party suicide gene-transduced anti-HLA-DPB1*0401 CD4+ T cells CTL 19",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic, third-party, CD4+ T lymphocytes that specifically recognizes the human leukocyte antigen (HLA)-DPB1*0401 and transduced with a suicide gene, with potential antineoplastic activity. Upon administration, allogeneic third-party suicide gene-transduced anti-HLA-DPB1*0401 CD4+ T cells CTL 19 specifically target and kill HLA-DPB1*0401-positive leukemic cells. The suicide gene causes the destruction of the T-cell clone upon the administration and presence of ganciclovir, which enhances the safety of the agent. HLA-DP is expressed by many leukemic cells.",
  "abbreviation": "CTL 19",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-third-party-suicide-gene-transduced-anti-hla-dpb1-0401-cd4-plus-t-ctl/"
}