autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD4+ and CD8+ T cells FH-MCVA2TCR

{
  "id": "MLC-T-ONC-011687",
  "term": "autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD4+ and CD8+ T cells FH-MCVA2TCR",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous CD4+ and CD62L-expressing CD8+ T cells transduced with a third generation lentiviral vector (LV) to express the high affinity T-cell receptor (TCR) A2 -MCC1, specific for the human leucocyte antigen (HLA)-A02-restricted Merkel cell polyomavirus (MCPyV; MCV) viral oncoprotein, with potential immunomodulating and antineoplastic activities. Upon reintroduction into the patient, the autologous MCPyV-specific HLA-A02-restricted TCR-transduced CD8+ and CD4+ T cells FH-MCVA2TCR selectively bind to the KLLEIAPNC epitope (KLL epitope) within the MCPyV viral oncoprotein. This results in cytotoxic T-lymphocyte (CTL)-mediated elimination of tumor cells expressing the MCPyV viral oncoprotein. Additionally, tumor-specific HLA-A02-restricted CD4+ cells promote class I-restricted CD8+ proliferation, survival and effector functions by producing interleukin (IL)-2 and facilitating the activation of dendritic cells (DCs). MCPyV viral oncoprotein is highly expressed in Merkel cell carcinoma (MCC) caused by MCPyV.",
  "synonyms": [
    "autologous CD8+ and CD4+ T cells transduced with TCR A2-MCC1",
    "FH-MCVA2TCR autologous CD8+ and CD4+ T cells transduced with TCR A2-MCC1"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-mcpyv-specific-hla-a02-restricted-tcr-transduced-cd4-plus-and-cd8-t/"
}