MCPyV TAg-specific polyclonal autologous CD8-positive T cell vaccine

{
  "id": "MLC-T-ONC-015035",
  "term": "MCPyV TAg-specific polyclonal autologous CD8-positive T cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of polyclonal autologous CD8 positive T-lymphocytes specific for the Merkel cell polyomavirus (MCPyV) T antigen (TAg) with potential antineoplastic activity. Peripheral blood lymphocytes from a Merkel cell carcinoma (MCC) patient were obtained and antigen-specific CD8+ T cells targeting a specific MCPyV TAg epitope were derived and expanded ex vivo. Upon infusion of the MCPyV TAg-specific polyclonal autologous CD8-positive T cell vaccine, the T cells recognize the MCPyV antigen and exert a cytotoxic T-lymphocyte response against the MCPyV TAg-expressing MCC cells. MCPyV is expressed in about 80% of MCC and is not expressed in normal, human tissue; the MCPyVTag oncoprotein plays a key role in MCC survival and tumor cell proliferation.",
  "synonyms": [
    "MCPyV TAg-specific polyclonal autologous CD8-positive T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mcpyv-tag-specific-polyclonal-autologous-cd8-positive-t-cell-vaccine/"
}