Mcl-1 inhibitor MIK665

{
  "id": "MLC-T-ONC-015034",
  "term": "Mcl-1 inhibitor MIK665",
  "field": "Oncology and biomedicine",
  "definition": "An inhibitor of induced myeloid leukemia cell differentiation protein (Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities. Upon administration, MIK665 binds to and inhibits the activity of Mcl-1, which promotes apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mcl-1-inhibitor-mik665/"
}