Mcl-1 inhibitor AZD5991

{
  "id": "MLC-T-ONC-015032",
  "term": "Mcl-1 inhibitor AZD5991",
  "field": "Oncology and biomedicine",
  "definition": "An inhibitor of induced myeloid leukemia cell differentiation protein (myeloid cell leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities. Upon administration, AZD5991 binds to Mcl-1, thereby preventing the binding of Mcl-1 to and inactivation of certain pro-apoptotic proteins, and promoting apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival.",
  "synonyms": [
    "MCL1 inhibitor AZD5991"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mcl-1-inhibitor-azd5991/"
}