MCL-1 inhibitor AMG 397

{
  "id": "MLC-T-ONC-015031",
  "term": "MCL-1 inhibitor AMG 397",
  "field": "Oncology and biomedicine",
  "definition": "An inhibitor of induced myeloid leukemia cell differentiation protein (myeloid cell leukemia-1; Mcl-1; Bcl2-L-3), with potential pro-apoptotic and antineoplastic activities. Upon administration, MCL-1 inhibitor AMG 397 targets and binds to Mcl-1, thereby preventing the binding of Mcl-1 to and inactivation of certain pro-apoptotic proteins. This promotes apoptosis of cells overexpressing Mcl-1. Mcl-1, an anti-apoptotic protein belonging to the B-cell lymphoma 2 (Bcl-2) family of proteins, is upregulated in cancer cells and promotes tumor cell survival.",
  "synonyms": [
    "myeloid cell leukemia 1 inhibitor AMG 397"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mcl-1-inhibitor-amg-397/"
}