MCL1 inhibitor GS-9716

{
  "id": "MLC-T-ONC-015033",
  "term": "MCL1 inhibitor GS-9716",
  "field": "Oncology and biomedicine",
  "definition": "An orally bioavailable inhibitor of the anti-apoptotic protein myeloid cell leukemia 1 (MCL1; induced myeloid leukemia cell differentiation protein; myeloid cell leukemia-1; Mcl-1; Bcl2-L-3), with potential antineoplastic activity. Upon oral administration, MCL1 inhibitor GS-9716 targets and binds to MCL1. This prevents the binding of MCL1 to and inactivation of certain pro-apoptotic proteins. This promotes apoptosis of cells overexpressing MCL1. MCL1, an anti-apoptotic protein belonging to the Bcl-2 family of proteins, is upregulated in cancer cells and promotes tumor cell survival.",
  "synonyms": [
    "Mcl-1 inhibitor GS-9716",
    "myeloid cell leukemia 1 inhibitor GS-9716"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/mcl1-inhibitor-gs-9716/"
}