Autologous polyclonal tumor infiltrating lymphocytes LYL845

{
  "id": "MLC-T-ONC-011751",
  "term": "Autologous polyclonal tumor infiltrating lymphocytes LYL845",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous, epigenetically reprogrammed, polyclonal tumor infiltrating lymphocytes (TILs), with potential immunomodulating and antineoplastic activities. The autologous TILs LYL845 are prepared and expanded ex vivo by co-culturing autologous tumor cells with specific Epi-R cell culture media containing optimized cytokine composition and cell activation which creates TILs enriched with CD8-positive T cells with diverse tumor-reactive clones and an enhanced proportion of stem-like T cells. Upon administration, the autologous TILs LYL845 may target and kill tumor cells and secrete pro-inflammatory cytokines. LYL845 shows increased durability of expanded TILs, enhanced polyclonality and increased tumor-reactive cytolytic T cells compared to TILs derived from the standard process.",
  "synonyms": [
    "autologous TILs LYL845"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-polyclonal-tumor-infiltrating-lymphocytes-lyl845/"
}