Allogeneic interleukin-17-producing CD8-positive T cells

{
  "id": "MLC-T-ONC-009910",
  "term": "Allogeneic interleukin-17-producing CD8-positive T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of allogeneic human cytotoxic T lymphocytes that express the pro-inflammatory cytokine interleukin-17 (IL-17; IL17), with potential immunomodulating and anti-tumor activities. Upon ex vivo stimulation, the IL-17-producing CD8-positive T cells (Tc17) convert to interferon-gamma (IFNg; IFN-g)-producing CD8-positive T cells (Tc1). Tc1 cells exert enhanced anti-tumor cytotoxicity. Human Tc17 cells may contribute to a number of human inflammatory and malignant diseases.",
  "synonyms": [
    "allogeneic IL-17-producing CD8+ T cells",
    "allogeneic Tc17 cells",
    "allogeneic IL-17+ CD8 T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/allogeneic-interleukin-17-producing-cd8-positive-t-cells/"
}