autologous mbIL-12-expressing tumor infiltrating lymphocytes GT202

{
  "id": "MLC-T-ONC-011686",
  "term": "autologous mbIL-12-expressing tumor infiltrating lymphocytes GT202",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of autologous tumor infiltrating lymphocytes (TILs) engineered to express membrane-bound interleukin-12 (mbIL-12), with potential immunomodulating and antineoplastic activities. The TILs are isolated from an autologous tumor sample and engineered to express mbIL-12. Upon infusion of the autologous mbIL-12-expressing TILs GT202 back into the patient, the cells specifically recognize, target and kill the patient's tumor cells. IL-12 expression activates the immune system by promoting the secretion of interferon-gamma (IFNg), activating natural killer cells (NKs), and inducing cytotoxic T-lymphocyte (CTL) responses, further killing tumor cells.",
  "synonyms": [
    "autologous TILs GT202",
    "autologous mbIL-12-expressing TILs GT202"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-mbil-12-expressing-tumor-infiltrating-lymphocytes-gt202/"
}