T-cell membrane-anchored tumor-targeted IL-12-modified tumor infiltrating lymphocytes

{
  "id": "MLC-T-ONC-016999",
  "term": "T-cell membrane-anchored tumor-targeted IL-12-modified tumor infiltrating lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of tumor infiltrating lymphocytes (TILs) engineered to express membrane-bound interleukin-12 (mbIL-12), with potential immunomodulating and antineoplastic activities. Upon infusion of the T-cell membrane-anchored tumor-targeted IL-12-modified TILs, the cells specifically recognize and kill the tumor cells. IL-12 expression activates the immune system by promoting the secretion of interferon-gamma (IFNg), activating natural killer cells (NKs), and inducing cytotoxic T-lymphocyte (CTL) responses, further killing tumor cells.",
  "synonyms": [
    "attIL12-TILs",
    "cell membrane-anchored tumor-targeted IL12-modified TILs",
    "mbIL-12-expressing TILs"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/t-cell-membrane-anchored-tumor-targeted-il-12-modified-tumor-infiltrating/"
}