cell membrane-anchored/CSV-targeted IL-12-expressing T lymphocytes

{
  "id": "MLC-T-ONC-012506",
  "term": "cell membrane-anchored/CSV-targeted IL-12-expressing T lymphocytes",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of T lymphocytes engineered to express cell membrane-anchored and cell-surface vimentin (CSV)-targeted interleukin-12 (IL-12), with potential immunostimulatory and antineoplastic activities. Upon administration, the cell membrane-anchored/CSV-targeted IL-12-expressing T lymphocytes are directed to and induce selective toxicity in CSV-expressing tumor cells. The cell membrane-anchored IL-12 cytokine promotes the secretion of interferon-gamma (IFNg), activates natural killer cells (NKs), and induces cytotoxic T-lymphocyte (CTL) responses against tumor cells locally, which may result in immune-mediated tumor cell death and the inhibition of tumor cell proliferation. Vimentin, overexpressed in various tumors, is associated with tumor growth and metastasis. Cell membrane-anchored IL-12 reduces the circulating levels of the inflammatory cytokine and the associated systemic adverse effects.",
  "synonyms": [
    "attIL12 armed T cells",
    "attIL12-expressing T-cells",
    "attIL12-T cells",
    "cell membrane-anchored/tumor-targeted IL-12-expressing T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cell-membrane-anchored-csv-targeted-il-12-expressing-t-lymphocytes/"
}