interleukin-12-Fc fusion protein DF6002

{
  "id": "MLC-T-ONC-014478",
  "term": "interleukin-12-Fc fusion protein DF6002",
  "field": "Oncology and biomedicine",
  "definition": "A fusion protein composed of human Interleukin-12 (IL-12) fused to a Fc fragment, with potential immunomodulatory and antineoplastic activities. Although the exact mechanism of action has not been completely characterized, upon administration, the IL-12 moiety binds to the IL-12 receptor. This may activate the immune system by promoting the secretion of interferon-gamma, activating natural killer cells (NKs), and inducing cytotoxic T-lymphocyte (CTL) responses, which may result in both decreased tumor cell proliferation and enhanced immune-mediated destruction of tumor cells.",
  "synonyms": [
    "IL12-Fc fusion protein DF6002"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/interleukin-12-fc-fusion-protein-df6002/"
}