DNA plasmid encoding interleukin-12 INO-9012

{
  "id": "MLC-T-ONC-013094",
  "term": "DNA plasmid encoding interleukin-12 INO-9012",
  "field": "Oncology and biomedicine",
  "definition": "A plasmid DNA vaccine encoding the human pro-inflammatory cytokine interleukin-12 (IL-12) with potential immunoactivating activity. Upon intramuscular delivery by electroporation of DNA plasmid encoding interleukin-12 INO-9012, IL-12 is translated in cells and activates the immune system by promoting the activation of natural killer cells (NK cells), inducing secretion of interferon-gamma and promoting cytotoxic T-cell responses against tumor cells. This may result in both immune-mediated tumor cell death and the inhibition of tumor cell proliferation.",
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/dna-plasmid-encoding-interleukin-12-ino-9012/"
}