PEG-PEI-cholesterol lipopolymer-encased IL-12 DNA plasmid vector IMNN-001

{
  "id": "MLC-T-ONC-015915",
  "term": "PEG-PEI-cholesterol lipopolymer-encased IL-12 DNA plasmid vector IMNN-001",
  "field": "Oncology and biomedicine",
  "definition": "A nanoparticle-based formulation composed of a non-viral plasmid DNA vector encoding the human pro-inflammatory cytokine interleukin-12 (IL-12) encapsulated in a biodegradable, biocompatible lipoplex composed of polyethylene glycol (PEG), polyethylenimine (PEI), and cholesterol, with potential immunoactivating and antineoplastic activities. Upon intraperitoneal (IP) delivery of the PEG-PEI-cholesterol lipopolymer-encased IL-12 DNA plasmid vector IMNN-001, the lipoplex is endocytosed by nearby cells, and the plasmid DNA is transported into the nucleus, which leads to local expresssion of IL-12. In turn, the increased IL-12 production at the tumor site activates the immune system by promoting the activation of natural killer cells (NKs), inducing secretion of interferon-gamma (IFN-g) and promoting cytotoxic T-cell responses against tumor cells.",
  "synonyms": [
    "phIL-12-005/PPC",
    "IL-12 plasmid formulated with PEG-PEI-cholesterol lipopolymer",
    "nanoparticle-encased IL-12 DNA plasmid vector",
    "phIL-12-005"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/peg-pei-cholesterol-lipopolymer-encased-il-12-dna-plasmid-vector-imnn-001/"
}