DNA plasmid encoding human IL-12 phIL12

{
  "id": "MLC-T-ONC-013093",
  "term": "DNA plasmid encoding human IL-12 phIL12",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of non-viral DNA plasmids encoding the human pro-inflammatory cytokine interleukin-12 (IL-12), constructed with a p21 promoter and devoid of an antibiotic resistance gene, with potential immunostimulating and antineoplastic activities. Upon administration of DNA plasmid encoding human IL-12 (hIL-12) phIL12 via intratumoral injection and electroporation, or gene electrotransfer (GET), the plasmid is introduced into human cells resulting in the expression and highly-localized secretion of IL-12 in the tumor microenvironment (TME). This activates the immune system by promoting the activation of natural killer cells (NKs), inducing the secretion of interferon-gamma (IFN-g) and promoting cytotoxic T-lymphocyte (CTL) responses against tumor cells. The switch from the constitutive promoter to the tumor-specific and genotoxic stress-inducible p21 promoter in the construction of phIL12 allows for high basal IL-12 expression in tumor cells. The lack of an antibiotic resistance gene improves the safety profile.",
  "synonyms": [
    "DNA plasmid encoding hIL-12 phIL12",
    "hIL-12-encoding DNA plasmid phIL12",
    "IL-12 DNA plasmid phIL12"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/dna-plasmid-encoding-human-il-12-phil12/"
}