tavokinogene telseplasmid

{
  "id": "MLC-T-ONC-016995",
  "term": "tavokinogene telseplasmid",
  "field": "Oncology and biomedicine",
  "definition": "A DNA plasmid that encodes genes for both the p35 and p40 subunits of the heterodimeric human interleukin 12 (hIL-12) protein that are separated by an internal ribosome entry site (IRES) and under the control of a single cytomegalovirus (CMV) promoter, with potential immunomodulatory and antineoplastic activities. Upon administration via intratumoral injection and electroporation, the plasmid is introduced into human cells resulting in expression and highly-localized secretion of a functional IL-12 p70 protein into the tumor microenvironment (TME). IL-12 is a pro-inflammatory cytokine that plays a significant role in priming and maintaining T-helper (Th) cells, activating natural killer (NK) cells, and regulating the reactivation and survival of memory T cells (Tm). Increased levels of IL-12 in the TME may augment host immune response against tumor cells by inhibiting regulatory T cells (Tregs), T-helper 2 (Th2) responses, and myeloid-derived suppressor cells (MDSCs).",
  "synonyms": [
    "tavo",
    "IT-Tavo-EP",
    "plasmid IL-12 pUMVC3-hIL-12-NGVL3"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/tavokinogene-telseplasmid/"
}