interleukin-12 gene

{
  "id": "MLC-T-ONC-014477",
  "term": "interleukin-12 gene",
  "field": "Oncology and biomedicine",
  "definition": "The DNA sequence that encodes the protein cytokine interleukin-12 (IL-12). When introduced as the complementary DNA (cDNA) form into tumor cells by, for example, a genetically engineered adenovirus vector, the transfected IL-12 cDNA expresses IL-12 which activates antitumoral natural killer (NK) cells and CD8+ T-cells and stimulates the secretion of interferon-gamma (IFN-gamma), potentially inhibiting tumor cell metastasis. This gene therapy may also result in IL-12-mediated inhibition of vascular endothelial growth factor (VEGF) and enhancement of matrix metalloproteinases (MMPs).",
  "abbreviation": "pIL-12",
  "synonyms": [
    "plasmid DNA encoding human interleukin-12",
    "plasmid IL-12"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/interleukin-12-gene/"
}