Recombinant interleukin-12

{
  "id": "MLC-T-ONC-016435",
  "term": "Recombinant interleukin-12",
  "field": "Oncology and biomedicine",
  "definition": "A recombinant form of the endogenous heterodimeric cytokine interleukin-12 with potential antineoplastic activity. Recombinant interleukin-12 binds to and activates its cell-surface receptor, stimulating the production of interferon-gamma (IFN) which, in turn, induces IFN-gamma-inducible protein-10 (IP-10) and so inhibits tumor angiogenesis.",
  "abbreviation": "IL-12",
  "synonyms": [
    "NM-IL-12",
    "interleukin-12",
    "cytotoxic lymphocyte maturation factor",
    "natural killer cell stimulatory factor",
    "recombinant human interleukin-12 (IL-12) cytokine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/recombinant-interleukin-12/"
}