Adenovirus-mediated human interleukin-12

{
  "id": "MLC-T-ONC-009699",
  "term": "Adenovirus-mediated human interleukin-12",
  "field": "Oncology and biomedicine",
  "definition": "A replication-incompetent adenovirus encoding human pro-inflammatory cytokine interleukin-12 (IL-12) (Ad.hIL-12), with potential immunomodulating and antineoplastic activities. Upon intratumoral administration, the adenovirus selectively infects and replicates in tumor cells, which may result in tumor cell lysis. Synergistically, IL-12 expressed by the adenovirus may activate the immune system by promoting the activation of natural killer cells (NKs), inducing secretion of interferon-gamma and inducing cytotoxic T cell responses against tumor cells, which may result in immune-mediated tumor cell death and inhibition of tumor cell proliferation.",
  "abbreviation": "Ad.hIL-12",
  "synonyms": [
    "adenovirus-interleukin-12"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/adenovirus-mediated-human-interleukin-12/"
}