Recombinant Newcastle disease virus-encoding interleukin-12 MEDI9253

{
  "id": "MLC-T-ONC-016449",
  "term": "Recombinant Newcastle disease virus-encoding interleukin-12 MEDI9253",
  "field": "Oncology and biomedicine",
  "definition": "An oncolytic viral agent containing the oncolytic, live-attenuated, replication-competent strain of the avian paramyxovirus Newcastle disease virus (NDV) that has been engineered to include a transgene encoding the human pro-inflammatory cytokine interleukin-12 (IL-12), with potential antineoplastic and immunostimulating activities. Upon administration, recombinant NDV-encoding IL-12 MEDI9253 specifically infects and replicates in cancer cells. This may result in a direct cytotoxic effect involving the lysis of tumor cells via apoptotic mechanisms and may eventually lead to an inhibition of cancer cell proliferation. The production and secretion of IL-12 may potentiate and strengthen the anti-tumor immune response and activates the immune system by promoting the activation of natural killer cells (NK cells), inducing secretion of interferon-gamma and promoting cytotoxic T-cell responses against tumor cells.",
  "synonyms": [
    "recombinant NDV-encoding IL-12 MEDI9253"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/recombinant-newcastle-disease-virus-encoding-interleukin-12-medi9253/"
}