recombinant modified vaccinia Ankara-5T4 vaccine

{
  "id": "MLC-T-ONC-016448",
  "term": "recombinant modified vaccinia Ankara-5T4 vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine comprised of a recombinant modified vaccinia Ankara (MVA) viral vector encoding the 5T4 fetal oncoprotein (MVA-h5T4). Vaccination with recombinant modified vaccinia Ankara-5T4 vaccine may stimulate the host immune system to mount a humoral and cytotoxic T lymphocyte (CTL) response against tumor cells expressing 5T4 fetal oncoprotein antigen, resulting in tumor cell lysis. The MVA viral vector, derived from the replication-competent strain Ankara, is a highly attentuated, replication-defective vaccinia strain incapable of virion assembly.",
  "abbreviation": "rV-5T4 VAC",
  "synonyms": [
    "recombinant MVA-5T4 vaccine",
    "vaccinia-5T4 antigen vaccine",
    "recombinant pox virus encoding 5T4 vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/recombinant-modified-vaccinia-ankara-5t4-vaccine/"
}