vaccinia-tyrosinase vaccine

{
  "id": "MLC-T-ONC-017440",
  "term": "vaccinia-tyrosinase vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A vaccine consisting of recombinant vaccinia virus, based on the modified vaccinia virus Ankara (MVA), that encodes the melanoma-associated antigen tyrosinase. Vaccination with vaccinia-tyrosinase may stimulate the host immune system to mount a cytotoxic T-cell response against tumor cells expressing tyrosinase. Tyrosinase is a melanoma-specific differentiation agent that catalyzes the synthesis of the melanin precursor L-3,4-dihydroxyphenylalanine (L-DOPA).",
  "synonyms": [
    "VACTYROS",
    "rV-TYR Vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/vaccinia-tyrosinase-vaccine/"
}