DNA plasmid-encoding interleukin-12 INO-9012/PSA/PSMA DNA plasmids INO-5150 formulation INO-5151

{
  "id": "MLC-T-ONC-013097",
  "term": "DNA plasmid-encoding interleukin-12 INO-9012/PSA/PSMA DNA plasmids INO-5150 formulation INO-5151",
  "field": "Oncology and biomedicine",
  "definition": "A DNA-based combined formulation composed of INO-5150, DNA plasmids encoding the tumor-associated antigens (TAAs) prostate-specific antigen (PSA) and prostate-specific membrane antigen (PSMA), and INO-9012, a plasmid DNA vaccine encoding the immune activator and pro-inflammatory cytokine human interleukin-12 (IL-12), with potential immunoactivating and antineoplastic activities. Upon intramuscular delivery of INO-5151 and electroporation of the PSA/PSMA DNA plasmid INO-5150, PSA and PSMA are translated in cells and elicit a cytotoxic T-lymphocyte (CTL) response against cancer cells expressing PSA and PSMA, resulting in tumor cell lysis. Upon electroporation of the DNA plasmid encoding IL-12 INO-9012, IL-12 is translated in cells and the expressed IL-12 activates the immune system by promoting the activation of natural killer cells (NK cells), inducing secretion of interferon-gamma (IFN-g) and promoting CTL responses against tumor cells. This boosts the immune response and results in increased CTL-mediated tumor cell death as compared with the administration of INO-5150 alone. PSA and PSMA are overexpressed on a variety of cancer cell types.",
  "synonyms": [
    "formulation INO-5150 with INO-9012",
    "INO-5150 with INO-9012",
    "INO-5150/INO-9012 formulation"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/dna-plasmid-encoding-interleukin-12-ino-9012-psa-psma-dna-plasmids-ino-5150-ino/"
}