PSA/PSMA/PSCA-encoding DNA plasmid vaccine PF-06755990

{
  "id": "MLC-T-ONC-016278",
  "term": "PSA/PSMA/PSCA-encoding DNA plasmid vaccine PF-06755990",
  "field": "Oncology and biomedicine",
  "definition": "A DNA vaccine consisting of plasmids encoding the tumor-associated antigens (TAAs) human prostate-specific antigen (PSA), prostate-specific membrane antigen (PSMA) and prostate stem cell antigen (PSCA), with potential immunostimulating and antineoplastic activities. Upon administration via intramuscular electroporation, the PSA/PSMA/PSCA-encoding DNA Plasmid Vaccine PF-06755990 expresses PSA, PSMA and PSCA, which may elicit a cytotoxic T-lymphocyte (CTL) response against tumor cells that are expressing PSA, PSMA and PSCA, resulting in tumor cell lysis. PSA, PSMA and PSCA are overexpressed on a variety of cancer cell types.",
  "synonyms": [
    "PSA/PSMA/PSCA-encoding pDNA vaccine PF-06755990"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/psa-psma-psca-encoding-dna-plasmid-vaccine-pf-06755990/"
}