AdC68 expressing PSA/PSMA/PSCA vaccine PF-06755992

{
  "id": "MLC-T-ONC-009653",
  "term": "AdC68 expressing PSA/PSMA/PSCA vaccine PF-06755992",
  "field": "Oncology and biomedicine",
  "term_source": "AdC68 Expressing PSA/PSMA/PSCA Vaccine PF-06755992",
  "definition": "A prime cancer vaccine comprised of a genetically engineered, replication-deficient chimpanzee adenovirus serotype-68 (AdC68) encoding the tumor-associated antigens (TAAs) human prostate-specific antigen (PSA), prostate-specific membrane antigen (PSMA) and prostate stem cell antigen (PSCA), with potential immunostimulating and antineoplastic activities. Upon administration of AdC68 expressing PSA/PSMA/PSCA priming vaccine PF-06755992, the adenovirus infects and expresses PSA, PSMA and PSCA. The expressed proteins may stimulate the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing PSA, PSMA and PSCA, thereby inducing tumor cell lysis. PSA, PSMA and PSCA are overexpressed on a variety of cancer cell types.",
  "synonyms": [
    "Chimpanzee adenovirus serotype-68-expressing PSA/PSMA/PSCA priming vaccine PF-06755992",
    "Chimpanzee Adenovirus Serotype-68 Expressing PSA/PSMA/PSCA Priming Vaccine PF-06755992"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/adc68-expressing-psa-psma-psca-vaccine-pf-06755992/"
}