adenovirus-PSA prostate cancer vaccine

{
  "id": "MLC-T-ONC-009702",
  "term": "adenovirus-PSA prostate cancer vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine composed of a genetically engineered, replication-deficient type 5 adenovirus carrying the human prostate-specific antigen (PSA), with potential immunostimulating and antineoplastic activities. Upon subcutaneous vaccination with the adenovirus-PSA prostate cancer vaccine, the adenovirus infects cells and expresses PSA. In turn, PSA may activate the immune system and may induce a cytotoxic T-lymphocyte response against PSA-expressing tumor cells. PSA, a tumor associated antigen, is expressed by prostate epithelial cells and is overexpressed in prostate cancer.",
  "synonyms": [
    "Ad/PSA vaccine",
    "adenovirus/PSA vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/adenovirus-psa-prostate-cancer-vaccine/"
}