AdGMCAIX-transduced autologous dendritic cells

{
  "id": "MLC-T-ONC-009703",
  "term": "AdGMCAIX-transduced autologous dendritic cells",
  "field": "Oncology and biomedicine",
  "definition": "Autologous dendritic cells (DCs) transduced with a recombinant, replication-defective adenoviral vector expressing the fusion gene granulocyte-macrophage colony-stimulating factor (GM-CSF) and carbonic anhydrase IX (CA-IX or CA9) (GMCA-9), with potential immunomodulating activity. The autologous DCs are transduced ex vivo and express the GMCA-9 fusion protein on the cell surface. Upon intradermal administration of the AdGMCAIX-transduced autologous DCs back into the patient, the DCs activate the immune system to both mount a cytotoxic T lymphocyte-mediated response against tumor cells positive for the CA9 antigen, and generate memory T cells. This may result in decreased tumor growth. CA9, also known as G250, is a renal cell carcinoma (RCC)-associated antigen and a member of the carbonic anhydrase family that contains a human leukocyte antigen (HLA)-A2.1-restricted epitope; it is found in a majority of renal cell carcinomas while absent in most normal tissues. The cytokine GM-CSF enhances the immunogenicity of CA9-based DC vaccines.",
  "abbreviation": "DC-AdGMCAIX",
  "synonyms": [
    "DCs expressing CMCA9 gene",
    "dendritic cells transduced with AdGMCA9 expressing GM-CSF-carbonic anhydrase IX fusion protein"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/adgmcaix-transduced-autologous-dendritic-cells/"
}