Gallium Ga 68 NY104

{
  "id": "MLC-T-ONC-013831",
  "term": "Gallium Ga 68 NY104",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate composed of NY104, a small molecule carbonic anhydrase IX (CAIX; carbonic anhydrase 9; CA9; G250)-targeting tracer comprised of an acetazolamide core, a hydrophilic spacer and the bifunctional, macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic acid (NOTA), labeled with the radionuclide gallium Ga 68, with potential use as a tracer for CAIX-expressing tumor cells during positron emission tomography (PET). Upon administration of gallium Ga 68 NY104, the NY104 moiety targets and binds to CAIX-expressing tumor cells. Upon binding, CAIX-expressing tumor cells can be detected during PET. CAIX, a member of the carbonic anhydrase family and a tumor-associated antigen (TAA), is found in a majority of renal cell carcinomas while absent in most normal tissues.",
  "synonyms": [
    "68Ga-NY104",
    "gallium Ga 68 NYM005",
    "68Ga-NYM005"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/gallium-ga-68-ny104/"
}