anti-CAIX CAR T cells

{
  "id": "MLC-T-ONC-010196",
  "term": "anti-CAIX CAR T cells",
  "field": "Oncology and biomedicine",
  "definition": "A preparation of T lymphocytes that have been genetically modified to express a chimeric antigen receptor (CAR) targeting the tumor-associated antigen (TAA) carbonic anhydrase IX (CAIX; carbonic anhydrase 9; CA9; G250), with potential immunostimulating and antineoplastic activities. Upon administration, anti-CAIX CAR T cells target and bind to CAIX-expressing tumor cells, thereby inducing selective toxicity in CAIX-expressing tumor cells. CAIX is a member of the carbonic anhydrase family that is found in a majority of renal cell carcinomas while absent in most normal tissues.",
  "synonyms": [
    "CAIX-targeted CAR T cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/anti-caix-car-t-cells/"
}