indium In 111-XYIMSR-01

{
  "id": "MLC-T-ONC-014438",
  "term": "indium In 111-XYIMSR-01",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate consisting of XYIMSR-01, a bivalent low molecular weight ligand targeting two separate sites on carbonic anhydrase IX (CAIX), conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and labeled with indium In 111 (111In), with potential imaging activity during single photon emission computed tomography (SPECT). Upon administration of indium In 111-XYIMSR-01, XYIMSR-01 targets and binds to CAIX-expressing tumor cells, followed by internalization and retention of the radioisotope. This allows for imaging of CAIX-expressing tumor cells upon SPECT. CAIX is overexpressed in various tumors and plays a key role in intra- and extracellular pH regulation, cancer cell progression, survival, migration and invasion.",
  "synonyms": [
    "111In-XYIMSR-01",
    "[111In]XYIMSR-01"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/indium-in-111-xyimsr-01/"
}