indium In 111 vofatamab

{
  "id": "MLC-T-ONC-014424",
  "term": "indium In 111 vofatamab",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate composed of vofatamab, a human immunoglobulin G1 (IgG1) monoclonal antibody directed against the fibroblast growth factor receptor type 3 (FGFR3) labeled, via a bifunctional chelate, with the radioisotope indium In 111, with potential use as an imaging agent upon single photon emission computed tomography/computed tomography (SPECT/CT). Upon administration of Indium In 111 vofatamab, the vofatamab moiety specifically targets and binds to FGFR3. Upon SPECT/CT imaging, FGFR3-expressing tumor cells can be visualized. FGFR3, a receptor tyrosine kinase upregulated or mutated in many tumor cell types, plays a key role in tumor cell proliferation.",
  "synonyms": [
    "111In-FPI-1967",
    "111In-vofatamab",
    "[111In]-FPI-1967",
    "[111In]-vofatamab"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/indium-in-111-vofatamab/"
}