Indium In 111 tabituximab barzuxetan

{
  "id": "MLC-T-ONC-014423",
  "term": "Indium In 111 tabituximab barzuxetan",
  "field": "Oncology and biomedicine",
  "definition": "A radioconjugate consisting of tabituximab, a humanized immunoglobulin G1 (IgG1) monoclonal antibody directed against Frizzled-10 (FZD10; CD350), conjugated to the diethylenetriaminepentaacetic acid (DTPA) chelator derivative barzuxetan and labeled with the gamma-emitting isotope indium In 111, which may be used to detect FZD10-expressing tumor cells upon gamma scintigraphy. Upon administration of indium In 111 tabituximab barzuxetan, tabituximab targets and binds to FZD10 expressed on tumor cells. This allows for visualization of FZD10-expressing tumor cells upon gamma scintigraphy. FZD10, a member of the Frizzled family of G protein-coupled receptors, is one of the components in the Wnt/beta-catenin signaling pathway that plays key roles in embryogenesis and cancer growth.",
  "synonyms": [
    "OTSA101-DTPA-111In",
    "indium In 111-labeled tabituximab barzuxetan",
    "111In tabituximab barzuxetan"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/indium-in-111-tabituximab-barzuxetan/"
}