indium In 111-pentetreotide

{
  "id": "MLC-T-ONC-004283",
  "term": "indium In 111-pentetreotide",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A radioactive drug used to find certain types of neuroendocrine tumors (tumors that form from cells that release hormones). Indium In 111-pentetreotide binds to a protein called somatostatin receptor, which is found on some neuroendocrine tumor cells. Indium In 111-pentetreotide builds up in these cells and gives off radiation that can be detected by a scanner to help show where the tumor cells are in the body.",
    "An indium 111 radioconjugate of pentetreotide, the diethylenetriaminopentaacetic (DTPA) conjugate of the human hormone somatostatin peptide analogue (octreotide), used for radioimaging neuroendocrine tumor cells. The pentetreotide moiety of indium In 111 pentetreotide binds to somatostatin receptors (SSTRs), especially type 2 receptors, present on the cell membranes of many types of neuroendocrine tumor cells. Upon binding and internalization, this radioconjugate allows for specific imaging of neuroendocrine tumors that overexpress somatostatin using scintigraphic imaging techniques. In addition, high dose indium In 111 pentetreotide may specifically deliver a cytotoxic dose of gamma radiation to SSTR-positive cells thereby killing SSTR-expressing tumor cells."
  ],
  "synonyms": [
    "Indium-In-111-Pentetreotide",
    "Indium-In 111 Pentetreotide",
    "Indium-111-DTPA-D-Phe-1-octreotide",
    "Indium-111 Octreotide DTPA",
    "Indium In-111 Pentetreotide",
    "Indium In 111-Pentetreotide"
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/indium-in-111-pentetreotide/"
}