indium In 111-CHX-A DTPA trastuzumab

{
  "id": "MLC-T-ONC-004281",
  "term": "indium In 111-CHX-A DTPA trastuzumab",
  "field": "Oncology and biomedicine",
  "definitions": [
    "A substance being studied in the imaging of breast cancer and some other types of cancer. It is made by attaching a radioactive substance called indium In 111 to the monoclonal antibody trastuzumab. Trastuzumab binds to the human growth factor receptor 2 (HER2/neu) on some breast cancer cells and on several other types of cancer cells. Indium In 111-CHX-A DTPA trastuzumab is a type of radioimmunoconjugate.",
    "An indium I 111-labeled trastuzumab with potential use as an imaging agent. Indium In 111 CHX-A DTPA trastuzumab is chemically conjugated via a bifunctional metal chelator molecule, 2-(p-isothiocyanatobenzyl)-cyclohexyl-diethylenetriaminepentaacetic acid (CHX-A DTPA), a backbone-substituted derivative of DTPA. This agent may allow radioimmunolocalization of HER2-positive cells. Trastuzumab, a recombinant humanized monoclonal antibody that selectively binds with high affinity to the extracellular domain of human epidermal growth factor receptor 2 (HER2), may elicit an antibody-dependent cellular cytotoxicity (ADCC) against tumor cells that overexpress HER2."
  ],
  "references": [
    "NCI Dictionary of Cancer Terms",
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/indium-in-111-chx-a-dtpa-trastuzumab/"
}