indium In 111-autologous CMV-pp65-LAMP mRNA-loaded dendritic cells

{
  "id": "MLC-T-ONC-014426",
  "term": "indium In 111-autologous CMV-pp65-LAMP mRNA-loaded dendritic cells",
  "field": "Oncology and biomedicine",
  "definition": "A radioimmunoconjugate composed of mature autologous dendritic cells (DCs) generated from peripheral blood leukocytes pulsed with mRNA encoding for a fusion protein comprised of the human cytomegalovirus (CMV) matrix protein pp65 (65 kDa lower matrix phosphoprotein; UL83) fused with the lysosome-associated membrane protein (pp65-LAMP) and radiolabeled with the isotope indium In 111, with potential ability to track DC migration upon single-photon emission computed tomography (SPECT)/ computed tomography (CT). Upon intradermal injection of the indium In 111-autologous CMV pp65-LAMP mRNA loaded DCs into the groin area, the DCs migrate in vivo to the inguinal lymph nodes. Upon SPECT/CT imaging, DC in vivo migration to the lymph nodes can be assessed.",
  "synonyms": [
    "indium In 111-labeled CMV pp65 peptide-pulsed autologous DCs",
    "111In-labeled pp65-LAMP mRNA-loaded mature autologous DCs",
    "indium In 111-CMV pp65-LAMP mRNA-pulsed autologous DCs",
    "111In-labeled autologous CMV-pp65-LAMP mRNA loaded dendritic cells"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/indium-in-111-autologous-cmv-pp65-lamp-mrna-loaded-dendritic-cells/"
}