autologous CMV-pp65-shLAMP-1 mRNA loaded dendritic cell vaccine

{
  "id": "MLC-T-ONC-011578",
  "term": "autologous CMV-pp65-shLAMP-1 mRNA loaded dendritic cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cancer cell vaccine consisting of autologous dendritic cells pulsed with mRNA encoding the human cytomegalovirus (CMV) matrix protein pp65 (65 kDa lower matrix phosphoprotein; UL83) as a fusion construct with a short peptide chimeric antigen from lysosome-associated membrane protein 1 (shLAMP-1), with potential antineoplastic and immunostimulatory activities. Upon vaccination, the autologous CMV-pp65-shLAMP-1 vaccine exposes the immune system to the CMV pp65 peptide, which may elicit a cytotoxic T-lymphocyte (CTL) response against CMV pp65-expressing tumor cells. The incorporation of shLAMP-1 may route CMV pp-65 antigens into the lysosomal compartment, resulting in enhanced MHC class II antigen presentation, thereby promoting CD4-positive T-cell responses. The CMV pp65 protein is the primary component of the enveloped sub-viral particle of CMV and is expressed in certain tumor types.",
  "synonyms": [
    "pp65-shLAMP-1 mRNA DCs",
    "autologous shLAMP-1-pp65-DCs",
    "autologous shLAMP-1-pp65-DC vaccine",
    "autologous shLAMP-1-pp65 mRNA-pulsed DC vaccine",
    "autologous pp65-shLAMP-1 DC vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/autologous-cmv-pp65-shlamp-1-mrna-loaded-dendritic-cell-vaccine/"
}