CMV pp65 peptide-loaded alpha-type-1 polarized dendritic cell vaccine

{
  "id": "MLC-T-ONC-012678",
  "term": "CMV pp65 peptide-loaded alpha-type-1 polarized dendritic cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A dendritic cell (DC)-based cancer vaccine composed of mature polarized DCs (alpha-type-1 polarized DCs) loaded with the human cytomegalovirus (CMV) phosphoprotein pp65 (UL83), with potential immunostimulatory and antineoplastic activities. Upon administration, the CMV pp65 peptide-loaded alpha-type-1 polarized DC vaccine exposes the immune system to the CMV pp65 peptide, which may result in a cytotoxic T-lymphocyte (CTL) response against CMV pp65-expressing tumor cells leading to tumor cell lysis. The CMV pp65 protein is the primary component of the enveloped subviral particle of CMV and is expressed in certain tumor types.",
  "synonyms": [
    "CMV pp65 peptide-loaded alpha-type-1 polarized DC vaccine",
    "cytomegalovirus pp65 peptide loaded alpha-type 1 polarized dendritic cell vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/cmv-pp65-peptide-loaded-alpha-type-1-polarized-dendritic-cell-vaccine/"
}