adenovirus-p53 transduced dendritic cell vaccine

{
  "id": "MLC-T-ONC-009701",
  "term": "adenovirus-p53 transduced dendritic cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine consisting of autologous dendritic cells (DCs) transduced with a recombinant adenovirus encoding p53 peptide, with potential immunomodulating activity. Intradermal vaccination with adenoviral-p53 transduced dendritic cell vaccine may stimulate the host immune system to mount a cytotoxic T lymphocyte (CTL) response against tumor cells expressing mutant p53, resulting in tumor cell lysis. p53, a tumor suppressor gene, is mutated in many tumor cells, resulting in the loss of apoptosis regulation and abnormal cell proliferation.",
  "synonyms": [
    "dendritic cell-P53"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/adenovirus-p53-transduced-dendritic-cell-vaccine/"
}