adenovirus HER2-transduced autologous dendritic cell vaccine

{
  "id": "MLC-T-ONC-009692",
  "term": "adenovirus HER2-transduced autologous dendritic cell vaccine",
  "field": "Oncology and biomedicine",
  "definition": "A cell-based cancer vaccine composed of autologous dendritic cells (DCs) transduced with a replication-deficient adenovirus vector encoding HER-2 with potential antineoplastic activity. Upon administration, adenovirus HER2-transduced autologous dendritic cell vaccine may stimulate a cytotoxic T lymphocyte (CTL) response against HER-2-positive tumor cells, which may result in tumor cell death and decreased tumor growth. HER-2, a tyrosine kinase receptor for epidermal growth factor (EGF) (also known as neu and ErbB2), is overexpressed by some breast, ovarian, and gastric cancers.",
  "abbreviation": "AdHer2/DC",
  "synonyms": [
    "autologous dendritic cell-adenovirus HER2 vaccine",
    "autologous dendritic cell/adenovirus HER-2 vaccine",
    "HER-2 pulsed DC vaccine"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/adenovirus-her2-transduced-autologous-dendritic-cell-vaccine/"
}