adenoviral PSA vaccine ETBX-071

{
  "id": "MLC-T-ONC-009676",
  "term": "adenoviral PSA vaccine ETBX-071",
  "field": "Oncology and biomedicine",
  "definition": "A cancer vaccine composed of a genetically engineered, replication-deficient adenovirus carrying the gene encoding human prostate-specific antigen (PSA), with potential immunostimulating and antineoplastic activities. Upon vaccination with the adenoviral-PSA vaccine ETBX-071, the adenovirus infects cells and expresses PSA. In turn, PSA activates the immune system and induces a cytotoxic T-lymphocyte (CTL) response against PSA-expressing tumor cells. PSA, a tumor associated antigen (TAA), is expressed by prostate epithelial cells and is overexpressed in prostate cancer.",
  "synonyms": [
    "Adenoviral PSA Prostate Cancer Vaccine ETBX-071"
  ],
  "references": [
    "National Cancer Institute Thesaurus"
  ],
  "url": "https://mlchart.com/terminology/oncology/adenoviral-psa-vaccine-etbx-071/"
}